Quantification of telomerase activity in sporadic colorectal carcinoma
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چکیده
منابع مشابه
Quantification of telomerase activity in normal oral mucosal tissue and oral squamous cell carcinoma
BACKGROUND AND OBJECTIVE The role of telomeres and telomerase in oral cancer is an area of much recent interest. The understanding of the role of telomere biology, the end replication problem leading to genomic instability and the reactivation of telomerase, is absolutely critical to our understanding of oral cancer, and more so, to our ability of early diagnosis and developing novel therapies ...
متن کاملTelomerase activity in oral squamous cell carcinoma.
BACKGROUND The riboprotein telomerase has been linked to cellular immortality and is believed to play a key role in tumorigenesis. OBJECTIVE To determine if telomerase is expressed in patients with oral squamous cell carcinoma. DESIGN Twenty patient samples of oral squamous cell carcinoma and 20 adjacent histologically normal mucosal samples were assayed using the telomeric repeat amplifica...
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OBJECTIVE The role of telomerase activity and telomere length in the adenoma-carcinoma sequence of colon carcinogenesis has not been well established. The objective of this study was to determine telomerase activity and telomere length patterns in patients with adenomatous polyps either associated or not with colorectal cancer, as well as the role of telomeric instability in the adenoma-carcino...
متن کاملTelomerase activity and telomere length in the colorectal polyp-carcinoma sequence
Objective: the role of telomerase activity and telomere length in the adenoma-carcinoma sequence of colon carcinogenesis has not been well established. The objective of this study was to determine telomerase activity and telomere length patterns in patients with adenomatous polyps either associated or not with colorectal cancer, as well as the role of telomeric instability in the adenoma-
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BRAF mutations are second to KRAS mutations in activation of the MAPK pathway in colorectal carcinoma cells. In addition to mutated KRAS, BRAF V600E mutation is associated with resistance to EGFR-targeted therapy in colorectal cancer; thus mutated BRAF might serve as a predictive factor. In this study, 163 routinely resected adenocarcinomas were screened for mutations in exons 11 and 15 of the ...
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ژورنال
عنوان ژورنال: Cancer
سال: 2000
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(20000315)88:6<1304::aid-cncr5>3.0.co;2-8